IN VITRO METHODS FOR IDENTIFYING MODULATORS OF MEMBERS OF THE STEROID/THYROID SUPERFAMILY OF RECEPTORS

摘要

In accordance with the present invention, there are provided in vitro methods for the large scale identification of modulators of members of the steroid/thyroid superfamily of receptors. Invention methods can be rapidly carried out employing large numbers of compounds per screen, thereby facilitating evaluation of large libraries of compounds in a relatively short time. Modulators identified employing invention methods are capable of activating a receptor species in the optional presence of one or more of: a heterodimerizing partner therefor, a co-activator (or co-suppressor), and/or a hormone response element; or of disrupting the activity of a receptor species in the presence or absence of one or more of: a heterodimerizing partner therefor, a co-activator (or co-suppressor), and/or a hormone response element.