ANTI-INFLAMMATORY CONTAINING MONOCLONAL ANTIBODIES HAVING REACTIVITY WITH SIALYL-LEWIS X SUGAR CHAINS ORIGINATING IN HEMANGIOENDOTHELIAL CELL MEMBRANE

摘要

A leukocyte rolling inhibitor, leukocyte adhesion inhibitor, leukocyte tissue infiltration inhibitor, and anti-inflammatory, each containing monoclonal antibodies having a reactivity with sialyl-Lewis X sugar chains originating in the hemangioendothelial cell membranes of nonlymphatic tissues (e.g., brain, trachea, lung, liver, heart, pancreas, intestine, mesentery, kidney, skin or joint), preferably further sialyl-Lewis X sugar chains originating in the cell membranes of leukocytes. The above monoclonal antibodies have not only all of the anti-inflammatory effects of the conventional monoclonal antibodies against each of L-, E- and P-selectin proteins, but also the effect of inhibiting the earliest stages of local tissue inflammation, i.e., the rolling and adhesion of leukocytes on a hemangioendothelial cell membrane and the infiltration of leukocytes into extravascular tissues. Therefore the invention provides a potent anti-inflammatory having a novel action mechanism.