Anti inflammatory agents containing monoclonal antibodies reactive to sialyl Ruiz x sugar chains derived from vascular endothelial cell membranes

摘要

Non lymphoid tissue (e.g., brain, trachea, lungs, liver, heart, pancreas, intestine, mesentery, kidney, skin, or joints), which is reactive to sialyl Ruiz x sugar chains derived from vascular endothelial cell membranes, preferably sialyl Ruiz x sugar chains derived from leukocyte membranes It relates to leukocyte rolling inhibitor, including leukocyte adhesion inhibitor, leukocyte adhesion inhibitor, and anti-inflammatory agent. The monoclonal antibodies in the present invention not only have the anti inflammatory action of each of the monoclonal antibodies to the conventional L -, e - or p-selece Kuching proteins, but also the earliest stage of the local tissue inflammation reaction process, i.e., white It has the effect of inhibiting the rolling and adhesion of blood cells on the vascular endothelial cell membrane and the infiltration of the leukocyte into the extravascular tissue. Accordingly, according to the present invention, a potent anti-inflammatory agent can be provided by a novel action mechanism without prior art.