Process for synthesizing cyclic depsipeptides

摘要

A process for the total synthesis of a cyclic peptide useful as an antifungal drug is disclosed as are novel compounds prepared by the method. The process for synthesizing a cyclic peptide represented by the following formula (I): CHEM wherein X1, X2, X4 and X7 are independently N-methyl- alpha -amino acid or alpha -hydroxy acid, provided that at least one of X1, X2, X4 and X7 is a alpha -hydroxy acid; X3, X6 and X8 are independently alpha -amino acid; X5 is a cyclic amino acid; X9 is a N-methyl- alpha -amino acid or alpha -hydroxy acid substituted by a hydroxy group; and the dotted lines represent intramolecular hydrogen bonds; comprises cyclizing a corresponding linear peptide between X5 and X6 via peptide bond, and a novel compound represented by the formula (I).