Benzocycloalkyl azorethion derivatives as dopamine beta-hydroxylase inhibitors (BENZOCYCLOALKYLAZOLETHIONE DERIVATIVES AS DOPAMIN BETA-HYDROXYLASE INHIBITORS)

摘要

The invention refers to the compound of dopamine, carotene, heidelot inhibitor, hohaexue (I) and the pharmaceutically permitted salt, different sex body and the mixture of these isomers, as well as the use method and manufacturing method of the benzophenone compound;In the above formula, n is 0, 1 or 2; t is 0, 1, 2 or 3; R1 is independently halo, hydroxy or (C1-4) alkyloxy; R2 is a group selected from the following formulas (a), (b) and (c), which are bonded at the α-, β- or γ-position:;The phenylmethylcycloalkyl part of the above compounds is phosphorus,1. 2, 3, 4-terahead, putari and 6, 7, 8, 9-terahead-5h-team huangengji (here,)The risk group was selected from 1 to 2 permutations;The azo part of the above compounds is 2-thiourea-2, 3, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 2, 3, 2, 2, 2, 2, 2, 2, 2, 2, 2, 3, 2, 2, 2, 2, 2, 2, 2, 2, 3, 2, 2, 2, 2, 2, 2, 25-t-ara-4,5-binary-1h - [1,2,4] triazole-iv, V, V, II, iv] triazole-i (they are selectively replaced by 1-3 permutations).