Recombinant human immunodeficiency virus carrier and method for producing same (Recombinant Human Immunodeficiency Virus Vector and Process for Producing the same)

摘要

The present invention relates to a method for producing a recombinant vector comprising the steps of: maintaining an exogenous DNA sequence that antagonizes the expression of HIV and / or gene of HIV, and that the U3 region of the LTR sequence on the 5 'side of the genome is replaced by a promoter sequence of cytomegalovirus Thereby providing a recombinant type HIV carrier.;The combination carrier of the present invention according to the present invention is useful as a material for gene therapy for HIV infection because HIV infection cells such as antisense, ribozyme, TAR decoy and the like are reliably expressed in HIV-infected cells.