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PREPARATION PROCESS OF ASPARTAME BY REDUCTION USING PALADIUM CATALYST
PREPARATION PROCESS OF ASPARTAME BY REDUCTION USING PALADIUM CATALYST
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机译:钯催化剂还原法制取天冬酰胺的工艺
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摘要
Benzyloxy carbonyl group which is amino protecting group of N-benzyloxy carbonyl- M-L-aspartyl-L-phenylalanine methyl ester can be removed by catalytic reduction of palladium catalyst. Said catalytic reduction is carried out in mixture of water and methanol, at 30 to 60 degree Celsius, at the pressure of 15 to 65 psi and at pH5.2 to 5.7. Due to the rapid rise of pH of the reaction, acetic acid or sodium acetate is used to maintain the pH of the reaction.
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