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Methods for recovering immunoglobulins from fractions generated during fractionation of human plasma
Methods for recovering immunoglobulins from fractions generated during fractionation of human plasma
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机译:从人血浆分离过程中产生的馏分中回收免疫球蛋白的方法
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摘要
The following steps are successively carried out to prepare a high-range immunoglobulin preparation. Fractionating the plasma from plasma stock and isolating one or more industrially available fractions substantially containing polyclonal immunoglobulin G to obtain one or more remaining fractions; Preparing a protein solution from the residual fraction obtained in the previous step or protein components contained in its sub-fraction; The resulting protein solution is applied to the hydrophilic chromatography using a fixed ligand of one or more ligand type so as to be once or more applied to bind the specific plasma protein to the ligand to remove the bound plasma protein and use it as a high-. The resulting immunoglobulin can be processed into a well-tolerated storage-stable product. This method of producing a valuable immunoglobulin preparation utilizes a plasma fraction of a person that has so far been rejected in conventional industrial plasma fractionation methods.
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