Novel Iridoid Derivatives That Inhibit Replication of Hepatitis B Virus and Methods for Preparing the Iridoid Derivatives

摘要

The present invention relates to novel iridoide derivatives of the general formula (I), pharmaceutically acceptable salts and isomers thereof which inhibit the replication of hepatitis B virus.;Where Represents a double bond or a single bond, R ₁ represents hydroxy or lower alkoxy, R ₂ is formyl; C ₁ -C ₅ aryl unsubstituted or substituted by one member selected from the group consisting of chloro, azido, substituted or unsubstituted amino, phenylthio or hydroxyimino; C ₂ -C ₅ alkenyl substituted or unsubstituted by ethoxycarbonyl or phenyl, or R ₁ and R ₂ together or Group, where n represents an integer from 0 to 2 and R ₃ represents hydroxy, acetoxy or C ₁ -C ₅ alkyl.;The present invention also relates to a method for preparing a compound of formula (I) and a pharmaceutical composition which can be used for the treatment of hepatitis B by containing the compound as an active ingredient.