首页>
外国专利>
AMIDES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING PROPERTY OF CHANNEL OPENING FOR CELLULAR POTASSIUM
AMIDES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING PROPERTY OF CHANNEL OPENING FOR CELLULAR POTASSIUM
展开▼
机译:纤维素钾通道的酰胺,合成方法和药物组合物的显示性能
展开▼
页面导航
摘要
著录项
相似文献
摘要
FIELD: organic chemistry. SUBSTANCE: product: amides of the formula (I): where: a): E - nitrogen and X - phenylsulfonyl; b): E - group CZ where C - ring carbon atom; Z - hydrogen, cyano-group, halogen, hydroxyl, alkyl or alkoxyl; X - phenylcarbonyl, phenylsulfinyl or phenyl sulfonyl; c): X - cyano-group and Z - phenylsulfonyl; R2 and R3 free alkyl or alkyl substituted with fluorine or they together form 3-5-membered cycloalkyl, and pharmcomposition based on amides of the formula (I) and methods of amide synthesis. Method 1. Reagent 1: the corresponding aniline. Reagent 2: the corresponding acid. Method 2. Reagent 1: amide of the formula (I) containing hydroxyl-protected group. Reaction condition: protective group removing. Method 3. Reagent 1: amide of the formula (I) where X - phenyl sulfide. Reagent 2: oxidizing agent. Synthesized compounds can be used in medicine. EFFECT: improved method of synthesis. 6 cl, 2 tbl
展开▼