2-SACCHARINYLMETHYL(ARYL OR ARYLHYDROXY) ACETATES, OR THEIR SALTS FORMED BY ADDITION OF ACIDS TO THESE BASIC COMPOUNDS, OR THEIR SALTS FORMED BY BASES ADDITION TO THESE ACID COMPOUNDS, AND PHARMACEUTICAL COMPOSITION INHIBITING ACTIVITY OF PROTEOLYTIC ENZYMES

摘要

FIELD: chemistry of heterocyclic compounds. SUBSTANCE: product: 2-saccharinylmethyl(aryl or arylhydroxy) acetates of the formula (I) where: m = 0 or 1; n = 0 or 1 and the sum m + n = 0 or 1; R¹ - H or lower alkyl; R² - H or lower alkyl; R³ - phenyl or phenyl substituted with 1-3 similar or different halogens; R⁴ - H, lower alkyl or lower alkoxy-group; R⁵- - H or 1-2 substituents at any of 5-, 6- or 7-position taken from lower alkyl, lower alkoxy-group, hydroxy(lower) alkyl, hydroxy(lower)alkoxy-group or their salts, and also pharmaceutical composition based on these compounds inhibiting activity of proteolytic enzymes. EFFECT: improved method of synthesis. 13 cl, 12 tbl