DERIVATIVES OF ARYL-SUBSTITUTED PIPERIDINES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, THEIR USE AND INTERMEDIATE COMPOUNDS OF SYNTHESIS

摘要

FIELD: organic chemistry. SUBSTANCE: product: new derivatives of aryl-substituted piperidines of the formula (I): $$$ where: Ar means pyrid-2-yl or free phenyl or phenyl substituted with halogen, methyl or $$$-alkoxyl; $$$ means methyl group; $$$ means hydrogen, or $$$ and $$$ together mean group $$$; $$$ means hydroxyl, $$$-alkoxyl, $$$-acylhydroxy-group, cyano-group, group $$$, group $$$, group $$$, group $$$, group $$$, $$$-acyl group, $$$-alkoxycarbonyl, group $$$, group $$$, $$$-alkoxymethyl, $$$-acyloxymethyl, $$$-alkylaminocarbonylhydroxymethyl, group $$$, group $$$, group $$$, group $$$, group $$$ or $$$ means double bond between carbon atom with which it is bound and adjacent carbon atom of piperidine ring; or Ar and $$$ together with carbon atom with which they were bound form group of the formula (a): $$$. Synthesized compounds were used as antagonists of receptors to neurokinin $$$. Invention relates to also method of synthesis of new piperidine derivatives and pharmcomposition based on thereof. Invention relates to also new intermediate compounds of piperidine derivatives synthesis. EFFECT: improved method of synthesis.