LINEAR OR CYCLIC OLIGOPEPTIDES SHOWING AFFINITY TO OPIOID RECEPTORS, PHARMACEUTICAL COMPOSITION, TREATMENT METHOD

摘要

FIELD: chemistry of peptides. SUBSTANCE: invention relates to new oligopeptides showing affinity to opioid receptors that are linear or cyclic ones at primary amino acid sequence in skeleton Tyr-X-Phe-Leu-Z where: X and Z mean amino acids or their derivatives and/or analogs and where X and Z can be bound by covalent linkage forming heterocyclic structure. In the latter Z is taken from Cys, Glu, Gly or derivatives of Glu and Gln; X is taken from amino acids or their analogs Ser, Glu, Pro, "АМЦК", D-Ala, D- or L-ornithine, D- or L-2,4-diaminobutyric acid, D- or L-Lys and D- or L-Cys. Invention also relates to pharmaceutical preparations containing above mentioned oligopeptides that can be used as analgetics for pain relieve, for depression, stress and shock treatment states. EFFECT: enhanced effectiveness of oligopeptides.