Cross-coupling reaction for prepn. of multi:nuclear aromatic cpds.

摘要

Prepn. of multinuclear aromatic cpds. comprises reacting an aromatic boron cpd. with an aromatic halogen cpd. or an aromatic perfluoroalkylsulphonate in the presence of a base, a Ni or Pd catalyst, a phosphorus contg. ligand and a polyhydric alcohol, sulphoxide or sulphone. Pref. the polyhydric alcohol, sulphoxide or sulphone are water soluble. The phosphorus contg. ligand is pref. water soluble and of the triaryl-phosphane, tri-n-alkyl-phosphane, dialkylaryl-phosphane, alkyldiaryl-phosphane or heteroaryl-phosphane type which may also include linkages via one or more metal atoms, phosphite, phosphinic acid ester, phosphonic acid ester, phosphole, dibenzophosphole and phosphorus atom contg. cyclic or oligocyclic and polycyclic cpds. The base is an alkali metal fluoride, alkali/alkali earth metal hydroxide, carbonate, acetate or alcoholate, alkali metal bicarbonate, or an amine. Aromatic chloro cpd. is esp. chlorobenzonitrile and aromatic boron cpd. is esp. p-toluene-boric acid.