Pharmaceutical preparations containing ruthenium (III) complexes which have an anti-tumor effect

摘要

The invention concerns complex compounds of general formula (I) {G}-(n+p+2r(p-1)-3){[RuX6-n-p-q-2rBn(H2O)p(OH)q(O)r]2r+1}n+p+2r(p-1 )-3, in which: n+p+2r(p-1)-3q NOTEQUAL 0; G is a suitable counterion but not a charged heterocycle; B is a mono- or polynuclear basic heterocycle with one or a plurality of nitrogen atoms; X represents halides, pseudohalides, HCO3-, RCOO-, in which R is C1-C6 aryl, alkenyl or alkyl (substituted or unsubstituted); n is 1, 2 or 3, but n+p NOTEQUAL 3; p is either 0 or 1, or 0 or 0.5p if r = 0.5; q is either 0 or 1, or 0 or 0.5q if r = 0.5, SIGMA n, p, q/=6; and r is 0 or 0.5. These compounds have a tumour-inhibiting effect with good solubility in water and are therefore suitable as chemotherapy agents for treating cancers.