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Compositions containing tramadol and any codeine, oxycode or hydrocode and their use
Compositions containing tramadol and any codeine, oxycode or hydrocode and their use
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机译:包含曲马多和任何可待因,羟考酮或氢可酮的组合物及其用途
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摘要
This invention relates to compositions comprising a tramadol material and any of codeine, oxycodone or hydrocodone, and their use. The compositions are pharmacologically useful in treating pain, diarrhea and tussive conditions. The compositions are also subject to less side-effects as compared to pure opiate based compositions, such as abuse liability, tolerance, constipation and respiratory depression. Furthermore, where the components, i.e., a tramadol material and any of codeine, oxycodone or hydrocodone, of the compositions are within certain ratios the pharmacological effects of the compositions are superadditive (synergistic). IMAGE
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