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METHOD FOR THE SYNTHESIS OF 2,6-DICHLOR-5-FLUORNICOTINIC ACID AND 2,6-DICHLOR-5-FLUORNICOTINOYL CHLORIDE
METHOD FOR THE SYNTHESIS OF 2,6-DICHLOR-5-FLUORNICOTINIC ACID AND 2,6-DICHLOR-5-FLUORNICOTINOYL CHLORIDE
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机译:2,6-二氯-5-氟烟碱酸和2,6-二氯-5-氟烟碱酰氯的合成方法
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摘要
An improved process for the preparation of 2,6-dichloro-5-fluoronicotinoyl chloride is described where a 2,6-dihydroxy-5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro-5-fluoronicotinoyl chloride and subsequent basic hydrolysis affords 2,6-dichloro-5-fluoronicotinic acid.
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