USE OF LIGANDS FROM THE PERIPHERAL BINDING SITES FOR BENZODIAZEPINES FOR THE PREPARATION OF DRUGS USEFUL IN THE TREATMENT OF PERIPHERAL NEUROPATHIES

摘要

The use of ligands for the peripheral bonding sites of benzodiazepines (p-sites) in the preparation of medicaments for the prevention and treatment of peripheral neuropathies is new. The preferred p-site ligands are of formula (I). X = H, halo, 1-4C alkyl, 1-4C alkoxy, CF3, CH3S, NO2, or NH2; Y1 = H, halo or 1-4C alkyl; Y2 = OH, 1-4C alkoxy, or SR; R = H, 1-4C alkyl, or (4-alkoxyphenyl)methyl; R1, R2 = H or 1-4C alkyl.