Separations by simulated moving bed chromatography operating at low K' values using weakly interating adsorbents as the stationary phase

摘要

Resolution of a mixture of organic materials by simulated moving bed chromatography using a weakly interacting adsorbent as a stationary phase can be routinely effected with a liquid mobile phase characterized by atypically low values of k' with recoveries of at least 95% and a purity of at least 95%. In particular, values in the range 0.1 k' 1.0 are recommended with a resulting savings in mobile phase consumption, inventory, and recovery.