Simulated Moving Bed Separation Process of Chromatography Using Flow Rate Increase

摘要

The present invention corrects for non-uniformity in the composition of the extract (EA) or extract residue (RB) due to the dead volume introduced by one or more recycle pumps (P) or compressors for liquid, supercritical or gas mixtures in the column closed circuit. In a simulated moving bed separation method, in each case an extract extraction flow (EA) or extract residue stream (RB) passes from an adjacent front position to an adjacent rear position for each dead volume in the circuit; The flow rate of the flow rate control recirculating pump or compressor is increased while the extract or extract residues remain in the rear position adjacent to the dead volume; Then, when the extract or extract residue extraction flow passes from the rear position adjacent to the dead volume to the next position, the flow rate of the recirculation pump or compressor is reduced to restore the value applied if the flow rate is ignored in the dead volume. It relates to a method characterized by.;The present invention is also applicable to the isomer separation of aromatic C ₈ hydrocarbon compounds.