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Liposomes containing polymerized lipids for non-covalent immobilization of proteins and enzymes

机译:含脂质的脂质体,用于非共价固定蛋白质和酶

摘要

The lipids of this invention are derivatives of phosphatidyl choline having the general chemical formula: ##STR1## wherein at least one of R and R' is a polymerizable unsaturated alkyl group, acid or ester, wherein X includes an iminodiacetic acid in the polymerizable metal chelating lipid (2) and wherein z is an integer from 1-20 including 1 and 20. Lipid microstructures are formed by mixing the polymerizable metal chelating lipid monomers (2) with polymerizable non-chelating lipid monomers wherein X includes a non-chelating group, for example, --N.sup.+ (CH.sub. 3).sub.3.
机译:本发明的脂质是具有以下化学通式的磷脂酰胆碱的衍生物:其中R和R'中的至少一个是可聚合的不饱和烷基,酸或酯,其中X在可聚合的基团中包含亚氨基二乙酸。金属螯合脂质(2),其中z是1-20的整数,包括1和20。脂质微结构是通过将可聚合的金属螯合脂质单体(2)与可聚合的非螯合脂质单体混合而形成的,其中X包括非螯合脂质组,例如--Nsup。+(CH.sub.3).sub.3。

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