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Preparation of 2',3'-didehydro-3'-deoxythymidine from 5- methyluridine
Preparation of 2',3'-didehydro-3'-deoxythymidine from 5- methyluridine
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机译:由5-甲基尿苷制备2',3'-二氢-3'-脱氧胸苷
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摘要
An economical process, amenable to large-scale production, is disclosed for the preparation of 2',3'-didehydro-3'-deoxythymidine (d4T) from 5-methyluridine. The process employs a novel, 5'-,acyl-2'- halo- 3'-alkanesulfonylthymidine intermediate as well as a highly efficient and practical deprotection, isolation and purification procedure for the d4T product.
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