Measurement of an enzyme marker as an aid to diagnosis of liver transplant rejection

摘要

A method which assists in the early diagnosis of rejection in a liver transplant recipient comprises measuring an increase in plasma or serum alpha glutathione S-.[.tranferase.]..Iadd.transferase.Iaddend.(&agr; - GST) from said recipient in the absence of or preceding any change in plasma or serum transaminase. &agr;-GST is most suitably measured by enzymeimmunoassay, using a solid phase antibody which is monospecific for &agr;-GST. The monospecific antibody cross-reacts with the &agr;-GST dimers B.sub.1 B.sub.1, B.sub.1 B.sub.2 and B.sub.2 B.sub.2.