PROTEIN FOR ACCELERATING HYDROLYSIS OF GTP

摘要

PROBLEM TO BE SOLVED: To obtain the subject new protein having an activity for accelerating the hydrolysis of GTP bound to a lipid-modified Rab3 subfamily member, and useful for clarifying mechanisms for releasing neurotransmitters and controlling the secretion of hormones and for clarifying relations with diseases. ;SOLUTION: This protein comprises a protein having an amino acid sequence of the formula or the amino acid sequence of the formula wherein one to several amino acids are replaced, deleted or added, and having an activity for specifically stimulating the hydrolysis of GTP bound to Rab3 subfamily member modified with a lipid. The protein is useful for clarifying mechanisms for controlling the release of neurotransmitters and the secretion of hormones and for clarifying the relations with diseases, etc., as a control factor specifically acting on the Rab3 subfamily member related to vesicle transport in cells. The protein is obtained by purifying a synaptic soluble fraction from a rat brain by column chromatography.;COPYRIGHT: (C)1998,JPO