Treatment of influenza virus infection using antiviral agents inhibit the acylation / palmitylation of hemagglutinin

摘要

(57) [Abstract] The present invention relates to an assay for identifying compounds that inhibit the assembly of the virus by suppressing palmitylation hemagglutinin of influenza virus (HA). In another aspect of the present invention, compounds which exhibit a good therapeutic index and prevents the assembly of the virus, the infection and / or replication is used to treat influenza infection. Somewhat, the present invention, the findings of the present applicant suppression of palmitylation of HA that to prevent the formation of infectious influenza virus mutations palmitylation sites of influenza virus HA is and affects the virus formation I based on.