Antiviral Potential of Catechins to Arrest Influenza Virus Infections with Confocal Microscopy, Molecular Docking and Mass Spectrometry

摘要

A combination of activity assays with confocal microscopy, sialidase inhibition assays, computer-based molecular docking and mass spectrometry show that catechins from tea leaves hold much promise as antiviral inhibitors to the influenza virus. Importantly they bind within the 430-cavity of influenza neuraminidase, remote from known drug resistant mutations, which render current antivirals ineffective.