And its use target-specific screening for the discovery of small organic molecule drug-like substance

摘要

(57) Thus, there is provided a variable domain of antibodies induced by recombinant [Abstract] The present invention, either or both of the H chain variable region and the L chain, with or without constant regions of each and selecting operation for the identification of the part surface or domain of the unique target of agents that modulate the function of the target, a domain that contains, on the general process. The recombinant antibodies are useful as a rapid screening reagent in a multi-occupancy capacity of the surface active domain with a substance of natural or synthetic. Further, the present invention is carried out to elucidate the three-dimensional conformation of the part or the antibody binds to the target of the drug, give the activity. It is also provides a method of constructing a molecular model of high resolution, the model is able to carry out the synthesis of small organic molecules active useful biological As an clues viable discovery drug.