MEDICINE COMPOSITION FOR TREATING GRAFT-VERSUS-HOST DISEASE (GVHD) AND FOR SUPPRESSING GRAFT REJECTION IN ORGAN TRANSPLANTATION

摘要

PROBLEM TO BE SOLVED: To obtain a preventive and a therapeutic agent having inhibitory actions on graft-versus-host disease and on graft rejection in organ transplantation, comprising a specific receptor agonist as an actives ingredient. SOLUTION: This composition comprises a retinoic acid receptor agonist, preferably a retinoic acid receptor subtype agonist as an active ingredient. Preferably, the agonist is a condensed ring-containing carboxylic acid derivative of the formula [L ring and R ring are condensed to form a (substituted) hetero ring; ring A and ring B are each (substituted) aromatic hydrocarbon or a (substituted) hetero ring; D is a (protected) carboxyl], to be concrete, 4- 2-[5-(5,8- dimethylnaphthalene-2-y1)pyrrolyl]benzoic acid or 4- 2-[5-(4,7- dimethylbenzofuran-2-y1)pyrrolyl]}benzoic acid.