TREATMENT OF INFANTILE HYPERSTELLAR CELL TUMOR INCLUDING BRAIN STEM NERVE GLIOCYSTOMA

摘要

PROBLEM TO BE SOLVED: To treat infantile hyperstellar cell tumors including brain stem nerve gliocystoma by administrating temozolomide. ;SOLUTION: Temozolomide of the formula (namely, 3,4-dihydro-3- methyl-4-oxoimidazo-[50,1-d] 1,2,3,4-tetrazine-8-carboximide) is administered. Preferably, the total dose of 50-1,200mg per 1m² body surface area of a patient is administered continuously during 5 days. In the case of the total dose 1,000mg/m², a daily dose of 200mg/m² is preferably administered for 5 days. Preferably, after a period of 28 days from the first day of the administration temozolomide is repeatedly administered. Otherwise, a smaller amount of dose is administered for a longer period. Preferably, a dose of 75mg/m² is administered for 6 to 7 weeks. temozolomide is mixed with anhydrous lactose NF, starch sodium glycolate NF, colloidal silicon dioxide NF, tartaric acid NF and stearic acid NF and can be administered in the form of capsule.;COPYRIGHT: (C)1998,JPO