首页>
外国专利>
PROSTAGLANDIN E2 RECEPTOR, ITS PRODUCTION, DNA CODING THE RECEPTOR, VECTOR COMPRISING THE DNA AND HOST CELL TRANSFORMED BY THE VECTOR
PROSTAGLANDIN E2 RECEPTOR, ITS PRODUCTION, DNA CODING THE RECEPTOR, VECTOR COMPRISING THE DNA AND HOST CELL TRANSFORMED BY THE VECTOR
展开▼
机译:前列腺素E2受体,其生产,编码受体的DNA,包含DNA的载体和由载体转化的宿主细胞
展开▼
页面导航
摘要
著录项
相似文献
摘要
PROBLEM TO BE SOLVED: To produce a new prostaglandin E2 receptor comprising a polypeptide containing a specific amino acid sequence, having an activities bonding to human prostaglandin E2 (PGE2 ) and transmitting the information and useful for treatment of a disease such as inflammatory caused by excess production of the PGE2 . SOLUTION: This prostaglandin E2 receptor is the new human EP3- V receptor comprising a polypeptide containing an amino acid sequence of the formula and having substantially pure form, or a homologue, a fragment having the sequence or its homologue. The PGE2 receptor is useful for prevention and treatment of a disease, such as inflammatory, caused by excess production of the PGE2 and further for screening of agonist and antagonist active material of the PGE2 , because the PGE2 receptor specifically bonding to the PGE2 . The PGE2 receptor is obtained by extracting RNA from human uterus tissue, etc., forming cDNA by using a reverse transcription enzyme, performing a PCR by using the cDNA as a primer, and screening a gene library by using the obtained cDNA as a probe.
展开▼