Benzamide Compounds, processes for preparing them and Pharmaceutical compositions containing them, method of tratamientoterapeutico and / or prevention with these compounds.And the applications of these compounds as Drugs and production of drugs.

摘要

We describe New Compounds derived from benzamides,Therapeutic Application of vasopressin antagonists; also have actividadvasodilatadora hypotensive and pharmacologically and other favourable Effects.The New Compounds have the formula (i), where R1 is alkyl, aryl or Heterocyclic, Cycle, each of which can be substituted with a Halogen among others; NO2, NH2, Oh,Acyl substituted or not; alquilosulfinilo acyl Acyl alquilosulfonilo; Bottom; aciloxi amino alkyl; aryl; alquilocarbamoiloxi; cyano; heterocycle; oxo substituted with aryl substituted or not,Aminoprotegido, a heterocycle, piridilo replaced with acyl substituted acyl Halogen, alquilamino acylamino substituted or not, alquilhidrazinocarbonilamino hydroxyimino Acyl alcoxiimino,,,Guanidine; R2 is H, alkyl or aryl substituted with Hydroxy acyl or not, or cycle, R3 is H, alkyl, halogen, Oh, aciloxisustituido or not, alkyl or alkoxy substituted or not with Oh,Alkoxy substituted or not with aryl, amino acyl, Oh, cn or NO2, Alquiltio, NH2, acyl or cicloalquiloxi; R4 is among other Halogen, NO2, Oh, NH2, alquilamino, aciloxi; amino alquilamino LowerAmino alquilamino Lower N - protected or not, alcoxisustituido with aryl acyl amino, Hydroxy, or guanidine, acylamino, a heterocycle substituted or not, Alquiltio; R5 is H, alkyl,Alkoxy or Halogen; a single link, or NH; and is alquileno, alquenileno - C: o -, - S (OR) 2 - or group - A - J - G, where G Is alquileno and J is o (where NR6 - R6 H or grupon - protected); X is - ch = CH -- ch = N or s; e is n or Ch.