Derivatives of 1,3 dihydro - 1 - (fenilalquenil) - 2H - imidazol - 2 - One, Process for their preparation, compositions containing Same,Procedure for and elicit that Composition and use of such compounds for preparing medicaments.

摘要

1. The invention refers to derivatives of 1,3-dihydro-1 (derivatives of phenyl-2h-pyridan-2-ona formula (I)), positive oxidation form, salt water added with acceptable acid or drug base on medicine and chemically acceptable plasma form. In these derivatives, R1 and R2 are hydrogen, C1-6 tar respectively, Formaldehyde, trifluoromethyl, cyclopropylpropylpropyl, a saturated 5 -,6- or 7 members containing one or two heteroatoms selected from oxygen, sulfur or nitrogen, indanyl, bicyl (2.2.1) -2-heptenyl, bicyl (2.2.1) heptanyl, C1-6 alkylsulfonyl, arylsulfonyl or substituted C1-10 alkyl ; R3 is hydrogen, halo or C1-6 alkynyloxy; R4 is hydrogen, cyano, optionally substituted C1-6 alkyl, C1-6 alkyloxycarbonyl or aryl; R5 is hydrogen, cyano; optionally substituted C1-6 alkyl, C1-6 alkyloxycarbonyl or aryl. Y is a direct bond or C1-3 alkanediyl; -A-B- is a bivalent radical having the formula -CR6 = CR7- or -CHR6-CHR7-. L is hydrogen, optionally substituted C1-6 alkyl C1-6 alkylcarbonyl, C1-6 alkyloxycarbonyl,C1-6 or arilsulfonil tar; arilo is the substituted phenyl. The definition of ldebe is supplemented by the following alternatives: alquenilo C3-6, arilo, pirideni, C1-C4 oarialoal quilo C1-C4. Het is mofflin or alternative pyridine glycol, pyridine, pyridine, furan or smallpox. Definition of alternative isoprene, furan, pyridine or tienilo with chlordecone and PDE IV inhibitor activity.1. Preparation procedure and use of compounds and compounds