A process for preparing a formulation of programmed Action of granules or spherical Nuclei containing 2,6-dimethyl 4 - (2-nitrophenyl) - 1.4 - dihidropiridin - 35 - Dimethyl dicarboxilato (Nifedipine)

摘要

A procedure for the preparation of a programmed Action formulation of granules or spherical Nuclei containing 2,6-dimethyl 4 - (2-nitrophenyl) - 1.4 - dihidropiridin - 35 - Dimethyl dicarboxilato (Nifedipine), where: (a) gru00e1nulosc ontienen Nuclei commonly denominadosesferas neutral Sugar content of Sugar and Starch can be,Sugar or Sugar and microcrystalline Cellulose and lactose; (b) a film that was adhieresobre kernels and APA that is obtained as a Solution, dispersion or emulsion containing NifedipineThe guys that are Solvent and Polymer Film and the programmed Action of the active substance; (c) a film that adheres to the previous aetapa kernels yield L (b) and thatObtained from a solutionDispersion or emulsion containing solvents and Polymers that are configuraruna Action programmed and Regulated to Nifedipine; Giving as a result gru00e1nulosqu and allow an actioN and default nifedipinadurante scheduled 24 hours, no Peaks or Valleys infraterapu00e9uticos and maintain Independence of pH from 1 to 85 and which enable the preparation of Management diferentesdosificaci ones.