PURIFIED AND FROM A HUMAN BONE ISOLATED INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF

摘要

Purified and isolated insulin-like growth factor binding protein (IGF) preparations I and II. The binding protein, known as the IGF-binding human bone-derived protein (hBD-IGFBP) potentiates the proliferative effects of IGF-II on bone marrow. Diagnostic studies for hBD-IGFBP as well as pharmaceutical compositions and their use for the manufacture of pharmaceutical compositions for the treatment of bone diseases, wound healing, skin repair and methods of modulating IGF activity in bone.