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Antibodies of soluble lymphotoxin b. receptors and antilymphotoxin receptor and ligand as therapeutic agents for the treatment of immunological diseases
Antibodies of soluble lymphotoxin b. receptors and antilymphotoxin receptor and ligand as therapeutic agents for the treatment of immunological diseases
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机译:可溶性淋巴毒素抗体b。受体和抗淋巴毒素受体和配体作为治疗免疫疾病的治疗剂
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摘要
This disclosure relates to compositions and methods comprising "lymphotoxin-² receptor blocking agents" which block lymphotoxin-² receptor signalling. Lymphotoxin-² receptor blocking agents are useful for treating lymphocyte-mediated immunological diseases, and more particularly, for inhibiting Th1 cell-mediated immune responses. This disclosure relates to soluble forms of the lymphotoxin-² receptor extracellular domain that act as lymphotoxin-² receptor blocking agents. This disclosure also relates to the use of antibodies directed against either the lymphotoxin-² receptor or its ligand, surface lymphotoxin, that act as lymphotoxin-² receptor blocking agents. A screening method for selecting soluble receptors, antibodies and other agents that block LT-² receptor signalling is provided.
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