1,3,4-oxadiazol-2(3H)-one Derivates, their preparation and their use as monoamine oxidase inhibitors.

摘要

The invention relates to 1,3,4-oxadiazol-2(3H)-one derivatives, of general formula (I) IMAGE in which R1 represents either a hydrogen atom or a linear or branched (C1-4)alkyl group, which is substituted by a hydroxyl, phenoxy, (C1-4)alkoxy, (C1-4)alkylthio, mercapto, (C1-4)alkoxy(C1-4)alkoxy, di(C1-4)alkylamino or N-(C1-4)alkyl-N-propynylamino group, or a (C3-4)alkynyl group, and R2 represents either a linear or branched (C1-8)alkyl group, which is substituted by one or a number of halogen atoms and/or a hydroxyl, 1-imidazolyl or 3-tetrahydropyranyl group, or a trifluoro(C3-5)alkenyl group, in the form of pure enantiomers or of mixtures of enantiomers, including racemic mixtures, and their addition salts with pharmaceutically acceptable acids. Application of them as monoamine oxidase, in particular MAO-B, inhibitors.