首页> 外国专利> PROCESS FOR PRODUCING PHARMACEUTICAL COMPOSITION CONTAINING IMMUNOGLOBULIN A, IMMUNOGLOBULIN B AND TRANSFERINE, AND THE ACTIVE COMPONENTS

PROCESS FOR PRODUCING PHARMACEUTICAL COMPOSITION CONTAINING IMMUNOGLOBULIN A, IMMUNOGLOBULIN B AND TRANSFERINE, AND THE ACTIVE COMPONENTS

机译:制备包含免疫球蛋白A,免疫球蛋白B和转铁蛋白以及活性成分的药物组合物的方法

摘要

(57) EXTRACT The present invention provides a plasma protein enhanced pharmaceutical antimicrobial, antitussive, and antiallergic pharmaceutical composition of 0.40-0.80 parts by weight of IgG and 0.15 parts by weight of heat atoms and 1 parts thereof. 0.45 parts by weight of transferrin, optionally inactivated and / or eliminated by the presence of infectious agents, is mixed with one or more known auxiliaries and / or excipients and formulated into a pharmaceutical formulation. The present invention further relates to a novel process for the preparation of active ingredients of a composition by heat-contacting a plasma fraction or plasma containing IgA, IgG and transferrin, if necessary, after inactivation and / or removal of any infectious agents present in an anion exchanger. , IgG and transferrin are mass-eluted in known manner, the precursor is separated from unwanted accompanying proteins, and IgA, IgG, and transferrin from precipitated, purified IgA, IgG and transferrin-containing cultures are precipitated, precipitated IgA, IgG esterferrin is released, lyophilized, and then activated by the infectious catabolism. ŕ
机译:(57)提取物本发明提供0.40-0.80重量份的IgG和0.15重量份的热原子及其1份的血浆蛋白增强的药物抗微生物,镇咳和抗过敏药物组合物。将0.45重量份的转铁蛋白与一种或多种已知的助剂和/或赋形剂混合,将其任选地通过感染剂的存在而失活和/或消除,并配制成药物制剂。本发明进一步涉及通过灭活和/或除去存在于宿主细胞中的任何感染剂后,如果需要的话,通过使包含IgA,IgG和转铁蛋白的血浆级分或血浆热接触,来制备组合物活性成分的新方法。阴离子交换剂。 ,IgG和转铁蛋白以已知方式大量洗脱,将前体与不需要的伴随蛋白分离,并从沉淀的,纯化的IgA,IgG和含转铁蛋白的培养物中沉淀出IgA,IgG和转铁蛋白,沉淀的IgA,IgG酯铁蛋白被沉淀出来,冻干,然后被传染性分解代谢激活。 ŕ

著录项

  • 公开/公告号HU214059B

    专利类型

  • 公开/公告日1997-12-29

    原文格式PDF

  • 申请/专利权人 IMMUNO AG.;

    申请/专利号HU19920000925

  • 发明设计人 EIBLJOHANN;EIBLMARTHA;LINNAUYENDRA;

    申请日1992-03-20

  • 分类号C07K16/06;A61K39/395;

  • 国家 HU

  • 入库时间 2022-08-22 02:57:55

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