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PEPTIDE COMPOSITIONS CAPABLE OF DOWN REGULATING AN ANTIGEN SPECIFIC IMMUNE RESPONSE

机译:肽组合物可向下调节抗原特异性免疫反应

摘要

Therapeutic compsns. as follows are claimed: compsn. 1 comprising at least one isolated peptide having a defined sequence of amino acid residues, the compsn. being capable of down-regulating an antigen specific immune response (ASIR) in a population of humans subject to the ASIR, when administered in non-immunogenic form; and compsn. 2 comprising at least one isolated and purified peptide having a defined length, a defined sequence of amino acid residues and comprising at least one T cell epitope of a protein antigen, the compsn. being capable of down-regulating an ASIR to the protein antigen in a population of humans subject to the ASIR when administered in non-immunogenic form.
机译:治疗药物。索赔如下:compsn。包含至少一种具有确定的氨基酸残基序列的分离的肽的组合物。当以非免疫原性形式给药时,能够在受ASIR的人群中下调抗原特异性免疫应答(ASIR);和compsn。 2包含至少一种分离的和纯化的肽,其具有确定的长度,确定的氨基酸残基序列并且包含至少一种蛋白质抗原的T细胞表位,所述复合物。当以非免疫原性形式给药时,能够将ASIR下调至受ASIR的人群中的蛋白质抗原。

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