PROCESS AND DIASTEREOMERIC SALTS USEFUL FOR THE OPTICAL RESOLUTION OF RACEMIC 'alpha'-4-(1,1-DIMETHYLETHYL)PHENYL-4-(HYDROXYDIPHENYLMETH YL)-1-PIPERIDINEBUTANOL AND DERIVATIVE COMPOUNDS.

摘要

A process and diastereomeric salts useful for the optical resolution of racemic 'alpha'-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmeth yl)-1-piperidinebutanol, 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybuty l]-'alpha','alpha'-dimethylbenzeneacetic acid and lower alkyl 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybuty l]-'alpha','alpha'-dimethylbenzeneacetates. The process comprises placing into solution a chiral resolving agent, either (+)/(-)-di-paratoluoyltartaric acid or (-)/(+)-mandelic acid, in an amount equimolar to a compound corresponding to the desired enantiomer of the above compound, precipitating the resulting diastereomeric salt between the chiral resolving agent and the target enantiomer and separating the enantiomer.