ANTIGENIC FRAGMENT COMMON TO SEVERAL RESPIRATORY SYNCYTIAL VIRUSES (RSV)

摘要

New polypeptides (I) useful as immunogenic elements comprise a peptide sequence between amino acids 130 and 230 of the protein G sequence of respiratory syncytial virus (RSV) subgroup A or B, or a sequence having at least 80% homology with this sequence. Also claimed are: (1) an immunogenic agent comprising a polypeptide (I) coupled to a carrier protein; (2) a compsn. for preventing and/or treating RSV subgroup A and/or B infections contg. a polypeptide (I) or an immunogenic agent as in (1); (3) a nucleotide sequence coding for a polypeptide (I); (4) a protein (namely Klebsiella pneumoniae p40 protein) with a defined sequence of 335 amino acids given in the specification, or with 80% homology with this sequence; (5) a nucleotide sequence coding for K.pneumoniae p40 protein; and (6) a process for preparing a peptide conjugate for use in the compsn. of (2).