SUSTAINED RELEASE MORPHINO-CONTAINING TABLET WITH A 'PUSH' COMPONENT OF POLY(ALKYLENE OXIDE) AND POLY(VINYL PYRROLIDONE) TO AID RELEASE

摘要

A bilayer comprising a morphine layer of morphine, poly(alkylene oxide) and poly(vinylpyrrolidone); and an expandable contacting layer of coated granules of a higher molecular weight poly(alkylene oxide) and a hydroxyalkylcellulose, which bilayer is disclosed for morphine therapy. A method is disclosed for using the bilayer composition.