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NON SELF-INACTIVATING, EXPRESSION TARGETED RETROVIRAL VECTORS CONTAINING LONG TERM REPEAT (LTR) REGIONS
NON SELF-INACTIVATING, EXPRESSION TARGETED RETROVIRAL VECTORS CONTAINING LONG TERM REPEAT (LTR) REGIONS
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机译:包含长期重复(LTR)区域的非自发表达靶向逆转录病毒载体
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摘要
The present invention relates to a retroviral vector undergoing promoter conversion comprising a 5'LTR region of the structure U3-R-U5; one or more sequences selected from coding and non-coding sequences; and a 3'LTR region comprising a completely or partially deleted U3 region wherein said deleted U3 region is replaced by a polylinker sequence, followed by the R and U5 region. The retroviral vector undergoes promoter conversion and is useful as a gene transfer vehicle for targeted gene therapy.
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