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Key intermediates in the manufacture of simvastatin and the process for manufacturing simvastatin from lovastatin or mevinolinic acid
Key intermediates in the manufacture of simvastatin and the process for manufacturing simvastatin from lovastatin or mevinolinic acid
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机译:辛伐他汀生产中的关键中间体以及由洛伐他汀或美维宁酸生产辛伐他汀的方法
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摘要
A process for preparing simvastatin from lovastatin or mevinolinic acid in salt form comprises treating either starting material with cyclopropyl or butyl amide, the pyranone ring thereby being opened when lovastatin is the starting material, adding a methyl group to the 2-methylbutyrate side chain, and thereafter closing the open pyranone ring to produce simvastatin. The process is performed without protecting and deprotecting the two hydroxy groups of the open pyranone ring. In a preferred embodiment, the starting material is treated with cyclopropyl amine which produces simvastatin via the novel intermediate lovastatin cyclopropyl amide.
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