Steroid derivatives for the treatment of prostatichyperthropy their preparation and uses.

摘要

Compounds of formula (I): CHEM [wherein: R1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl; R2 is: aryl-substituted alkyl, aromatic heterocyclic-substituted alkyl or diarylamino; and R3 is carboxy or a group of formula -CONHSO2 R4 wherein R4 is alkyl]; and pharmaceutically acceptable salts and esters thereof have valuable 5 alpha -reductase inhibitory activity and can thus be used for the treatment and prophylaxis of, inter alia, prostatic hypertrophy as well as other disorders arising from excess levels of 5 alpha -dihydro-testosterone.