PROCESS FOR THE PREPARATION OF MICROGRANULES SUITABLE FOR SUSPENSION AFTER COATING IN PHARMACEUTICAL LIQUID COMPOSITIONS

摘要

Object of the invention is a process for the preparation ofmicrogranules to be used after coating in liquid pharmaceuticalcompositions, particularly in controlled-release compositions.Operating with high-shear mixer-granulators within clearlyestablished crucial parameter ranges, this process permits to obtainmicrogranules having a particle size distribution, a density, asurface and a shape which make them particularly suitable forcoating and to be subsequently suspended in fluids.