USE OF HUMAN CB2 RECEPTOR AGONIST COMPOUNDS FOR THE PREPARATION OF IMMUNOMODULATING DRUGS, NOVEL HUMAN CB2 RECEPTOR AGONISTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The use of human [err] receptor-specific agonists offormula (I) or (I') for preparing immunomodulating drugs isdisclosed. In formulae (I) and (I'), [err] is a group selected from[err][err][err] group; [err] and [err] are hydrogen, halogen or[err] alkyl; [err] is hydrogen, [err] alkyl or a group selected from [err] group;R4 has one of the meanings given for [err] or is a [err] group; [err] is hydrogen, [err] alkyl, [err] alkoxy, a halogen atom, a CF3 group, an[err] group or [err] alkylthio; [err] has one of the meanings given for Rs and is in the 5 or 6 position of the indene ring; R6 is hydrogenor [err] alkyl; [err] is [err] alkyl; R7 has one of the meanings given for [err] or [err] and [err] together form a [err] group attached to theindole ring in the 7 position by a group Y; [err] is phenyl substituted one to four times by a substituent selected from halogen, [err] alkyl or[err] alkoxy, a polycyclic ring selected from naphth-l-yl, naphth-2-yl, 1,2,3,4-tetrahydronaphth-l-yl, 1,2,3,4-tetrahydronaphth-5-yl, anthryl,benzofuryl, benzothien-2-yl, benzothien-3-yl, 2-, 3-, 4- or 8-quinolyl, said polycyclic rings optionally being substituted once or twice by asubstituent selected from [err] alkyl, [err] alkoxy, [err] alkylthio, halogen, cyano, hydroxyl, trifluoromethyl and imidazol-l-yl; [err] and [err]together are a group selected from [err] and [err] wherein the carbon atom substituted by [err] and [err] isattached to the nitrogen atom; [err] is [err] alkyl; or [err] and [err] taken together with the nitrogen atom to which they are attached, form agroup selected from morpholin-4-yl, thiomorpholin-4-yl, piperidin-l-yl and pyrolidin-1-yl; each of [err] and [err] is independently hydrogenor [err] alkyl; n is 2, 3, 4 or 5; p is 2 or 3; Z is a methyl group or a halogen atom; and Y is a methylene group or an oxygen atom.