GLYCOSYL ETOPOSIDE PRODRUGS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN COMBINATION WITH FUNCTIONALIZED TUMOR-SPECIFIC ENZYME CONJUGATES

摘要

The present invention relates to glycosyl-etoposide prodrugs, process for their preparation and their use in combination with functionalised tumour-specific enzyme conjugates for the treatment of cancers, and it specifically relates to 4'-O-glycosyl-etoposides as prodrugs which can be cleaved to cytotoxic agents on exposure to tumour-specific enzyme conjugates, where the liberated agent is suitable, by reason of its cytostatic activity, for the treatment of cancers.