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METHOD FOR THE PRODUCTION OF POLYVALENTS AND PHYSIOLOGICALLY DEGRADABLE CARBOHYDRATE RECEPTOR BLOCKERS BY ENZYMATIC GLYCOSYLATION REACTIONS AND THE USE THEREOF FOR THE PRODUCTION OF CARBOHYDRATE BUILDING BLOCKS
METHOD FOR THE PRODUCTION OF POLYVALENTS AND PHYSIOLOGICALLY DEGRADABLE CARBOHYDRATE RECEPTOR BLOCKERS BY ENZYMATIC GLYCOSYLATION REACTIONS AND THE USE THEREOF FOR THE PRODUCTION OF CARBOHYDRATE BUILDING BLOCKS
The invention relates to a process for producing polyvalent polymer-based carbohydrate receptor blockers which in vivo do not, either in their complete form or when broken down, provoke intolerance reactions. The carbohydrate side chain of the receptor blocker is built up directly on the biodegradable polymer by enzymatic glycolisation reactions in aqueous buffer systems and homogenous phase; the yields of these glycolisation reactions are considerably better than those of known processes, generally progress quantitatively and the accumulation densities are markedly increased. Also proposed is a process for producing free oligosaccharides using the carbohydrate receptor blockers produced according to the invention.
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