(+) - 6- (5-chloropyrid-2-yl) -7-oxo-vinyloxycarbonyloxy-5,6-dihydropyrrolo (3,4-b) pyrazine and their use in a method of preparation of (+) - 6- (5 -cloropirid-2-yl) -5- (4-methylpiperazin-1-yl) carbonyloxy-7-oxo-5,6-dihydro (3,4b) pyrazine.

摘要

(+) - 6- (5-chloropyrid-2-YL) -7-OXO-5-vinyloxycarbonyloxy-5,6-dihydro (3,4b) PYRAZINE AND THEIR USE FOR PREPARATION PROCEDURE (+) - 6- (5-chloropyrid-2-yl) -5- (4-methylpiperazin-1-yl) carbonyloxy-7-OXO-5,6-dihydro (3,4b) PIRAZINA.LA PREPARING (+) - zopiclone FROM OF (+) - 6- (5-chloropyrid-2-YL) -7-OXO-5-vinyloxycarbonyloxy-5,6-dihydro (3,4b) PYRAZINE OBTAINED BY eNZYMATIC RESOLUTION OF racemate USING AS lipase CUNDIDA ANTARCTICA A cATALYST IN PROCESS step under mild conditions and in good yields.