Chemically modified oligonucleotide with a view to a site-directed mutagenesis.

摘要

A TRIPLE MUTAGENIC FORMATION OLIGONUCLEOTIDE AND METHODS FOR USE WHERE THE OLIGONUCLEOTIDE IS CHEMICALLY MODIFIED TO INCORPORATE A TRIPLE FILAMENT NUCLEIC NUCLEIC ACID MOLECULA WITH A SEGMENT OF DNA SPECIFIC DURING TRIPLEZ FORMATION, THE MUTAGEN APPROACHES THE TARGET MOLECULA AND CAUSES THE MUTATION IN A SPECIFIC LOCATION OF THE SAME. THE ACTIVE, INACTIVE MUTATION OR ALTERS THE ACTIVITY AND FUNCTION OF THE OBJECTIVE MOLECULA.